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dhodh inhibitor aslan003  (MedChemExpress)


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    MedChemExpress dhodh inhibitor aslan003
    Dhodh Inhibitor Aslan003, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dhodh inhibitor aslan003/product/MedChemExpress
    Average 92 stars, based on 3 article reviews
    dhodh inhibitor aslan003 - by Bioz Stars, 2026-02
    92/100 stars

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    Enzymatic <t> Inhibitor </t> Activity of Compounds 2 – 5 , Brequinar, Bay2402234, ASLAN003, and 1 , with relative LogD 7.4 , Solubility, and Protein Binding <xref ref-type= a " width="250" height="auto" />
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    Enzymatic Inhibitor Activity of Compounds 2 – 5 , Brequinar, Bay2402234, ASLAN003, and 1 , with relative LogD 7.4 , Solubility, and Protein Binding <xref ref-type= a " width="100%" height="100%">

    Journal: Journal of Medicinal Chemistry

    Article Title: Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Biphenyl Moiety

    doi: 10.1021/acs.jmedchem.0c01549

    Figure Lengend Snippet: Enzymatic Inhibitor Activity of Compounds 2 – 5 , Brequinar, Bay2402234, ASLAN003, and 1 , with relative LogD 7.4 , Solubility, and Protein Binding a

    Article Snippet: A second acid DHODH inhibitor in a clinical trial, in addition to brequinar, is ASLAN003 (ASLAN Pharmaceuticals), which is currently being evaluated in a phase IIa clinical trial in AML patients (NCT03451084).

    Techniques: Activity Assay, Solubility, Protein Binding

    Enzymatic Inhibitor Activity of Compounds 6 – 17 and Relative LogD 7.4 , Solubility, and Protein Binding <xref ref-type= a " width="100%" height="100%">

    Journal: Journal of Medicinal Chemistry

    Article Title: Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Biphenyl Moiety

    doi: 10.1021/acs.jmedchem.0c01549

    Figure Lengend Snippet: Enzymatic Inhibitor Activity of Compounds 6 – 17 and Relative LogD 7.4 , Solubility, and Protein Binding a

    Article Snippet: A second acid DHODH inhibitor in a clinical trial, in addition to brequinar, is ASLAN003 (ASLAN Pharmaceuticals), which is currently being evaluated in a phase IIa clinical trial in AML patients (NCT03451084).

    Techniques: Activity Assay, Solubility, Protein Binding

    Analysis of the Biological Activity (Enzymatic Inhibitor Activity, Differentiation, Apoptosis, and Cytotoxicity) of Compounds 1 , 11 , 13 , 15 – 17 on THP-1 and U937, Compared to Brequinar, BAY-2402234, and 1 <xref ref-type= a " width="100%" height="100%">

    Journal: Journal of Medicinal Chemistry

    Article Title: Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Biphenyl Moiety

    doi: 10.1021/acs.jmedchem.0c01549

    Figure Lengend Snippet: Analysis of the Biological Activity (Enzymatic Inhibitor Activity, Differentiation, Apoptosis, and Cytotoxicity) of Compounds 1 , 11 , 13 , 15 – 17 on THP-1 and U937, Compared to Brequinar, BAY-2402234, and 1 a

    Article Snippet: A second acid DHODH inhibitor in a clinical trial, in addition to brequinar, is ASLAN003 (ASLAN Pharmaceuticals), which is currently being evaluated in a phase IIa clinical trial in AML patients (NCT03451084).

    Techniques: Activity Assay